RadiationDosimetry.com

Major Accomplishments

• Alanine-EPR Dosimetry System: Designed and built the first EPR-based dosimetry service to establish NIST-traceability for the irradiation processing industry.
• Homeland Security: Worked with multiple agencies and industrial partners to certify and safely apply irradiation technologies for the sanitation of postal mail contaminated by the anthrax-spore terrorist attack.
• Biodosimetry: First successful application of EPR dosimetry to bone tissue from gamma-ray radiation accident victims, and then again for an electron-beam related accident.
• Food Irradiation: Pioneered the use of EPR dosimetry for the detection of irradiated foods and worked with international partners and agencies to draft the first laboratory protocols.
• Quality System Manager: As the architect of the NIST Ionizing Radiation Division Quality System, devised the system framework, wrote manuals, policies, and technical protocols, and built the first (and currently only) web-disseminated NIST Quality System.
• Documentary Standards: Co-wrote the first ASTM standard for high-dose dosimetry using alanine-EPR dosimetry. Recently authored a comprehensive book chapter detailing the essential elements and features of an EPR dosimetry system.
• Summer Undergraduate Research Fellowship (SURF) Program: Building on a small Physics Laboratory summer program, expanded the opportunities for young scientists and engineers (many from under-represented groups) to engage in one-on-one research projects by building partnerships with the remaining Laboratories of NIST to construct a much larger institute-wide summer research program that serves the entire nation and US territories.

Employment

Consultant, 2017 – present
National Institute of Standards and Technology, 1986 – 2017
Argonne National Laboratory, 1984 – 1986

Professional History

Marc F. Desrosiers, a research chemist at the National Institute of Standards and Technology from June 1986 to January 2017, received his B.S. in chemistry from Boston College in 1978, and his Ph.D. in inorganic chemistry from the University of California at Santa Barbara in 1983. Dr. Desrosiers was a radiation chemist (as a Postdoctoral Fellow) at the Argonne National Laboratory in Illinois from 1984-86. As a member of the Ionizing Radiation Division (1986 to 2017), Dr. Desrosiers’ research includes radiation metrology and the development of standards and services.

Research Activities

Dr. Desrosiers designed and built a national and international program in industrial radiation metrology based on electron paramagnetic resonance (EPR) dosimetry. The EPR dosimetry technique is based on the use of an EPR spectrometer to quantify the radiation-induced free radicals in irradiated materials. His efforts have focused in several areas that include fundamental EPR dosimetry research, industrial-dosimetry development, radiological research, documentary standards (both national and international), and international collaborations.

Dr. Desrosiers developed the NIST EPR dosimetry facility that comprises several state-of-the-art EPR spectrometers. NIST and NPL are the premier national metrology institutes that use EPR as a quantitative technique in ionizing radiation dosimetry. Dr. Desrosiers used EPR measurements as a means of transfer dosimetry for ionizing radiation, that is, as a tool to precisely compare the yields of paramagnetic centers produced by radiation from a radiation source to be calibrated and those from the NIST source, whose dose rate has been accurately determined by water calorimetry (based on the NIST primary standard for absorbed dose in water). Small alanine pellets or alanine thin film strips on are placed in the radiation beam; following irradiation, the signal, which is directly proportional to the number of produced free radicals, is read out on an EPR spectrometer. Dr. Desrosiers and his team have systematically evaluated the factors affecting alanine-EPR response and the sources of possible inaccuracies of the method. Considerable effort has been spent on reducing the uncertainties of EPR spectrometry itself. A technique developed by Dr. Desrosiers’ team is the use of an in situ ruby standard that has enabled them to factor out measurement fluctuations from the electronic system and external influences, in order to achieve reproducibility that is unparalleled in EPR dosimetry. In addition, research from this team on the effects of irradiation temperature, storage humidity, and dose rate has advanced this dosimetry system to a new level of understanding and accuracy.

After September 11, 2001, the entire country was concerned with terrorism and homeland security. Scientists at all government laboratories were considering how they could help. The next act of terrorism was the mailing of anthrax spores that started on October 17, 2001. The US government, through the White House Office of Science and Technology (OSTP) needed a rapid but effective response to deal with quarantined mail in the Brentwood DC and Trenton NJ processing centers. From his expertise and experience with radiation-processing dosimetry and his support of the medical-device sterilization and food-irradiation industries, Dr. Desrosiers prepared complete explanations, procedures and contacts for irradiation of the mail. This won agreement throughout the federal-laboratory and national-laboratory network, the OSTP and the US Postal Service. Working with the Armed Forces Radiation Research Institute (AFRRI) on the radiobiology and radiation effects, NIST was able to coordinate industrial irradiations of test mail carrying NIST dosimeters and AFRRI spore (surrogate spore of bacillus globigi) to validate the sanitizing process. It is important to note that this real-life test was done by November 1, 2001, within two weeks of the anthrax mailing, largely due to the diligence of Dr. Desrosiers and his team. His work has continued on this important multi-agency project, helping the industrial irradiators to optimize their process, increasing throughput while sparing the mail much of the radiation damage experienced at the beginning. This work includes the validation of new procedures (high-energy x-rays rather than direct electron-beam irradiation) for parcel irradiation and dose-modifying protocols, testing effects of such irradiation on forensic evidence, and effects on the archival quality of irradiated mail. The irradiation of mail continues for selected government agencies, as does NIST involvement.

Quality System Management

Dr. Desrosiers was tasked with designing the framework and authoring the documents that would comprise the first NIST Radiation Physics Division (RPD) Quality System. The quality system is the organizational structure, responsibilities, procedures, processes and resources for the management of RPD calibration services and standard reference material production. The system was built on a series of operational manuals, policy guides, and technical procedures. The Division-level Quality Manual contains policies, guides and procedures established and maintained by the Radiation Physics Division to meet its technical needs. RPD Guides were written to establish the operational aspects of quality system. Examples include protocols for the management of complaints, nonconformance, and audits. RPD Procedures are the standard operating procedures for the RPD services and standard reference materials. Dr. Desrosiers wrote the RPD Procedure for the alanine-EPR transfer dosimetry service that enables a broad range of industries to achieve NIST traceability for their operations. These include, but are not limited to: medical device sterilization, aerospace device performance testing, biotech materials processing, food and agriculture safety, blood product safety, and a wide array of consumer products manufactured by irradiation modification of polymeric materials that include inks, coatings, thin films and wire insulation. As Division Quality Manager for over 15 years, Dr. Desrosiers conducted internal audits of all Division services and successfully guided the Division through three external audits resulting in internationally recognized declarations of compliance with the requirements for international acceptance of its services in commerce.

Radiological Research

Building on an early background in organometallic mechanistic photochemistry and organic radiation chemistry, Dr. Desrosiers maintained an interest in mechanisms of radiation interactions with biochemical systems. Several early publications focused on EPR spin-trap techniques of short-lived free radicals to elucidate their radiation-induced pathways. His major contributions in this area have been in the development of EPR/bone dosimetry as a method for post-irradiation detection of irradiated bone tissue. In published works that include Nature, his publications in the use of EPR for the detection of irradiated foods and for establishing dose to bone for radiation accident victims have established NIST leadership in these fields. The first successful application of EPR bone dosimetry for radiation accidents was achieved in a study of San Salvadorian radiation accident victims and then again for a detailed investigation of a radiation accident victim at an electron accelerator facility in Maryland. The latter work resulted in a cover article in the journal Health Physics. Dr. Desrosiers’ team was also the first to measure radiation dose to bone for a radiopharmaceutical injection of a bone-seeking agent being considered as a new bone-marrow ablation drug. On a national level, Dr. Desrosiers coordinated an interagency program for the development of dosimetry standards for radiobiology through the NIAID/NCI/NIST-sponsored workshop on Radiation Dosimetry Standardization for Radiobiology was held in 2011. The workshop goals were to highlight the importance and necessity of dosimetry standardization in radiation research, whether it involves in vitro or in vivo approaches, or large or small animal models, and to discuss the future of radiation dosimetry standardization, including a formal system for coordinating standardization efforts as well as the establishment of a continuing education series through national conference tutorials, publications, and web-based resources. Before retiring from NIST, new programs were initiated to expand the current lower limit (20 Gy) of alanine dosimetry to include therapy level dosimetry (as low as 1 Gy) for small-field radiation treatment applications (e.g., TomoTherapy or GammaKnife).

International Activities

Since 1989, Dr. Desrosiers has been a key organizer and editor of the series of international symposia on EPR dosimetry. In 1991 he organized and hosted the 3rd International Symposium on EPR Dosimetry at NIST; in 1995 he was the chief editor of the 4th International Symposium. In 1993, he co-organized an international school on EPR dosimetry at the Elba International Physics Center in Italy. Dr. Desrosiers has served on several coordinated research committees for the International Atomic Energy Agency (IAEA), which have included: Detection Methods for Irradiated Foods; Radiation Inactivation of Bioterrorism Agents; and, Radiation Treatment of Biohazardous Contaminants. Dr. Desrosiers serves on a number of writing groups of the ASTM dealing with industrial radiation dosimetry, and also serves as Chairman of the ASTM working group that wrote the Standard Practice for Alanine/EPR Dosimetry, now in worldwide use by industrial facilities.

NIST Positions

NIST internal positions held by Dr. Desrosiers include: Equal Employment Opportunity (EEO) Coordinator for the Physics Laboratory (PL), Director of the Summer Undergraduate Research Fellowship (SURF) Program underwritten by the NSF, and Senior Program Analyst in the NIST Director’s Program Office. In his duties as EEO Coordinator and Director of the SURF Program, Dr. Desrosiers visited US colleges, universities, and student conferences to promote careers at NIST in the sciences, often addressing students in under-represented groups. In his duties as Director of the SURF Program, Dr. Desrosiers managed the SURF program that brings undergraduates in science curricula to work for a summer with NIST staff on scientific projects. Dr. Desrosiers grew this program from a small 20-student program who summered in the Physics Laboratory to a much larger (150+ student) program that now includes all scientific laboratories at NIST. As a Program Analyst, Dr. Desrosiers was involved in the program planning, budget requests, and briefings at the highest levels at NIST. Because of his outstanding work, Dr. Desrosiers was asked to stay on for an additional term to supervise the Program Office (as Senior Program Analyst). One of his major accomplishments in the Program Office was the establishment of a benchmarking exercise that compared programs, resources and capabilities of NIST with those at other major national metrology institutes (e.g., Germany, Japan, Brazil).

Publications

Dr. Desrosiers has written over 100 archival publications (full list in following section).

By topic:
28 – Alanine Dosimetry
22 – Biodosimetry
20 – Dosimetry
18 – Food Irradiation
11 – Radiation Chemistry
5 – Homeland Security

Awards

Department of Commerce Bronze Medal for creative research and development of Electron Paramagnetic Resonance dosimetry (1991).

NIST Equal Opportunity/Diversity Award for developing Summer Undergraduate Research Fellowship (SURF) Program (1999).

Arthur S. Flemming Award (2002) for developing alanine/EPR technology to the highest metrological quality for measuring the absorbed dose in ionizing-radiation processing.

Education

Ph.D., Inorganic Photochemistry, University of California at Santa Barbara, 1983
B.S., Chemistry, Boston College, 1978

104. Alanine-EPR High-Dose Radiation Metrology, M.F. Desrosiers (2014) In, Applications of EPR in Radiation Research (A. Lund, M. Shiotani, Eds.) Springer International Publishing, pp. 489-507.

103. EPR and OSL emergency dosimetry with teeth: A direct comparison of two techniques, S. Sholom and M.F. Desrosiers, Radiat. Meas., 71 (2014) 494-497.

102. Effects of Dose Fractionation on the Response of Alanine Dosimetry, B. Lundahl, J. Logar, M. Desrosiers, and J. Puhl, Radiat. Phys. Chem., 105 (2014) 94-97.

101. The Importance of Dosimetry Standardization in Radiobiology, Marc Desrosiers, Larry DeWerd, James Deye, Patricia Lindsay, Mark K. Murphy, Michael Mitch, Francesca Macchiarini, Stahinja Stojadinovic, and Helen Stone, NIST J. of Res., 118 (2013) 403-418.

100. Post-Irradiation Study of the Alanine Dosimeter, M.F. Desrosiers, NIST J. of Res., 119 (2014) 277-295.

99. A Comparison of Harwell & FWT Alanine Temperature Coefficients from 25 °C to 80 °C, M.F. Desrosiers, A.M. Forney, and J.M. Puhl, NIST J. of Res., 117 (2012) 143-153.

98. Supplementary comparison CCRI(I)-S2 of standards for absorbed dose to water in Co-60 gamma radiation at radiation processing dose levels, D.T. Burns, P.J. Allisy-Roberts, M.F. Desrosiers, P.H.G. Sharpe, M. Pimpinella, V. Lourenço, Y.L. Zhang, A. Miller, V. Generalova, V. Sochor, Metrologia, 48 (2011) Tech. Suppl. 06009 1-18 (link is external).

97. Alanine as a Small Field Dosimeter – First Tests in Gamma Knife Radiosurgery Fields, J. Novotny Jr., M.F. Desrosiers, M.S. Huq, G. Bednarz, J.M. Puhl, and S.M. Seltzer, in press

96. UV Effects in Tooth Enamel and Their Possible Application in EPR Dosimetry with Front Teeth, S. Sholom, M. Desrosiers, V. Chumak, N. Luckyanov, S. Simon, and A. Bouville, Health Physics 98 (2010) 360-368.

95. The Impact of Industrial Irradiation Temperature Estimations on the Accuracy of Dosimetry, M. Desrosiers, T. Ostapenko and J. Puhl, Radiat. Phys. Chem. 78 (2009) 457-460.

94. Absorbed-Dose / Dose-Rate Dependence Studies for the Alanine-EPR Dosimetry System, M. Desrosiers and J. Puhl, Radiat. Phys. Chem. 78 (2009) 461-464.

93. A Study of the Alanine Dosimeter Irradiation Temperature Coefficient from 25 °C to 80 °C, M. Desrosiers, M. Peters and J. Puhl, Radiat. Phys. Chem. 78 (2009) 465-468.

92. Discovery of an Absorbed-Dose / Dose-Rate Dependence for the Alanine-EPR Dosimetry Systems and Its Implications in High-Dose Ionizing Radiation Metrology, M.F. Desrosiers, J.M. Puhl, S.L. Cooper, NIST J. of Res., 113 (2008) 79-95.

91. Irradiation Decontamination of Postal Mail: Lessons Learned and Future Opportunities, M.F. Desrosiers, S.M. Seltzer, J.M. Puhl, P.M. Bergstrom, L.T.Hudson, S.L. Cooper, IAEA TECH-DOC.

90. EPR tooth dosimetry of SNTS area inhabitants, S. Simon, M. Desrosiers, S. Sholom, A. Bouville, N. Luckyanov and V. Chumak, Radiat. Meas. 42 (2007) 1037-1040.

89. X-Ray and Gamma-Ray Absorbed Dose Profiles in Teeth: An EPR and Modelling Study, S. Sholom, C. O’Brien, E. Bakhanova, V. Chumak, M. Desrosiers, and A. Bouville, Radiat. Meas. 42 (2007) 1196-1200.

88. A Method for Establishing e-Traceability to Ionizing Radiation National Standards, S.L. Cooper and M.F. Desrosiers, Proceedings of Alanine Dosimetry for Clinical Applications, Physikalisch-Technische Bundesanstalt Report, PTB-Dos-51 (2006) pp. 46-51.

87. Next-Generation Services for e-Traceability to Ionizing Radiation National Standards, M.F. Desrosiers, J.M. Puhl, and S.L. Cooper, Proceedings of Alanine Dosimetry for Clinical Applications, Physikalisch-Technische Bundesanstalt Report, PTB-Dos-51 (2006) pp. 41-45.

86. CCRI supplementary comparison of standards for absorbed dose to water in ⁶⁰Co gamma radiation at radiation processing dose levels, D.T. Burns, P.J. Allisy-Roberts, M.F. Desrosiers, V. Yu. Nagy, P.H.G. Sharpe, R.F. Laitano, K. Mehta, M.K.H. Schneider, Y. Zhang, Radiat. Phys. Chem. 75 (2006) 1087-1092.

85. Time Dependence of the Radiation-induced EPR Signal in Sucrose, Marc Desrosiers and Samara Wadley, Radiat. Prot. Dosim. 118 (2006) 479-481.

84. An Absorbed Dose Map of Bone Tissue Treated with a Radiopharmaceutical In Vivo, M.F. Desrosiers, P. Fattibene and F. Le, Health Physics 92 (2007) 176-178.

83. A Transferability Study of the EPR-Tooth Dosimetry Technique, S. Sholom, V. Chumak, M.F. Desrosiers and A. Bouville, Radiat. Prot. Dosim. 120 (2006) 210-215.

82. Barium Dithionate as an EPR Dosimetric Material for Radiation Accidents, M.P. Baran, O.A. Bugay, S.P. Kolesnik, V.M. Maksimenko, V.V. Teslenko, T.L. Petrenko, M.F. Desrosiers, Radiat. Prot. Dosim. 120 (2006) 202-204.

81. A Study of the Irradiation Temperature Coefficient for L-Alanine and DL-Alanine Dosemeters, M.F. Desrosiers, M. Lin, S.L. Cooper, Y. Cui, and K. Chen, Radiat. Prot. Dosim. 120 (2006) 235-237.

80. Irradiation Decontamination of Postal Mail and High-Risk Luggage, M.F. Desrosiers, B.M. Coursey, S.M. Seltzer, L.T.Hudson, P.M. Bergstrom, F.B. Bateman, J.M. Puhl, S.L. Cooper, D.J. Alderson, G.B. Knudson, T.B. Elliott, M.O. Shoemaker, S. Miller and John Dunlop, NATO Science Series I: Life and Behavioural Sciences – Vol. 365 (L.G. Gazsó and C.C. Ponta, Eds.) In, “Radiation Inactivation of Bioterrorism Agents”, IOS Press, Netherlands (2005) pp. 115-126.

79. Irradiation Applications for Homeland Security, M.F. Desrosiers, Radiat. Phys. Chem. 71(2004) 479-482.

78. Characterization of a New Alanine Film Dosimeter: Relative Humidity and Post-Irradiation Stability, R.M.D. Garcia, M.F. Desrosiers, J.G. Attwood, D. Steklenski, J. Griggs, A. Ainsworth, A. Heiss, P. Mellor, D. Patil and J. Meiner, Radiat. Phys. Chem. 71 (2004) 375-380.

77. Next-Generation Services for e-Traceability to Ionizing Radiation National Standards, M.F. Desrosiers, M. Klemick, J.M. Puhl, D. Uchida, and S. Mallis, Radiat. Phys. Chem. 71(2004) 371-374.

76. A Study of the Alanine Dosimeter Irradiation Temperature Coefficient in the -77 °C to +50 °C Range, M.F. Desrosiers, S.L. Cooper, J.M. Puhl, A.L. McBain, and G.W. Calvert, Radiat. Phys. Chem. 71(2004) 365-370.

75. Quantitative Dose Response of Dry Free-Flowing Bacillus anthracis Strain Ames Spores after ⁶⁰Co-γ-gamma Photon Irradiation. G.B. Knudson, T.B. Elliott, M.O. Shoemaker, W.E. Jackson, R.J. Lowy, M.F. Desrosiers, B.G. Harper, D.D. Martin, J.D. Wright, Armed Forces Radiobiology Research Institute Special Publication 05-3 (2005).

74. Standard Practice for Use of the Alanine-EPR Dosimetry System, M.F. Desrosiers and A.H. Heiss, International Standards Organization & American Society for Testing and Materials, Designation ISO/ASTM 51607: 2004(E).

73. NIST Accelerator Facilities and Programs in Support of Industrial Radiation Research, F. B. Bateman, M. F. Desrosiers, L. T. Hudson, B. M. Coursey, P. M. Bergstrom Jr., S. M. Seltzer, in Proc. 17^th International Conference on the Application of Accelerators in Research and Industry, Denton, TX, JL Duggan & IL Morgan, Amer. Inst. Phys., New York 680 (2003) 877.

72. Ionizing Radiation Inactivation of Vaccinia Virus Using Gamma Photons, R. Joel Lowy, C.C. Broder, Y.R. Feng, M.F. Desrosiers, T.B. Elliott, Armed Forces Radiobiology Research Institute Special Publication 03-2 (2003).

71. Uncertainties in alanine dosimetry in the therapeutic dose range, V. Nagy, S. V. Sholom, V. V. Chumak, M.F. Desrosiers, Appl. Radiat. Isot. (2002) 917-929.

70. EPR dose reconstruction of two Kazakh villages near the Semipalatinsk nuclear test site, A. Romanyukha, M. Desrosiers, O. Sleptchonok, C. Land, N. Luckyanov, B.I. Gusev, Applied Magnetic Resonance (2002) 347-356.

69. e-Calibrations: Using the Internet to Deliver Calibration Services in Real Time at Lower Cost, M. Desrosiers, V. Nagy, J. Puhl, R. Glenn, R. Densock, D. Stieren, B. Lang, A. Kamlowski, D. Maier, A. Heiss, Radiat. Phys. Chem. (2002) 759-763.

68. Electron Paramagnetic Resonance Biodosimetry, M.F. Desrosiers and D.A. Schauer, Nucl. Instrum. Meth. B,184 (2001) 219-228.

67. Correction factors in EPR dose reconstruction for the residents of the Middle and Lower Techa riverside, A.A., Romanyukha, S. Seltzer, M. Desrosiers, E.A. Ignatiev, D.V. Ivanov, S. Bayankin, M.O. Degteva, F.C. Eichmiller, A. Wieser, P. Jacob, Health Physics, 81 (2001) 554-566.

66. The Next-Generation in Traceability: e-Calibrations, M.F. Desrosiers and V. Nagy, Measurement Science Conference Proceedings, eDoc Publish Inc., www.eDocPublish.com (2001).

65. Individual Biodosimetry at the Natural Radiation Background Level, A.A. Romanyukha, V. Nagy, O. Sleptchonok, M.F. Desrosiers, J. Jiang, A. Heiss, Health Physics 80 (2001) 71-73.

64. Reply to letter to the editor by R. B. Hayes, M.F. Desrosiers, V.Yu. Nagy, O.F. Sleptchonok, Radiat. Phys. Chem. 59 (2000) 445-447.

63. Advancements in Accuracy of the Alanine Dosimetry System. Part 3: Usefulness of an adjacent reference sample, V.Yu. Nagy, O.F. Sleptchonok, M.F. Desrosiers, R.T. Weber, A.H. Heiss, Radiat. Phys. Chem. 59(2000) 429-441.

62. Temperature Stabilization of Alanine Dosimeters Used for Food Processing and Sterilization, A. Bugay, S. Kolesnik, K. Mehta, V. Nagy, M.F. Desrosiers, Appl. Radiat. Isot. 52 (2000) 1371-1373.

61. Current Issues on EPR Dose Reconstruction in Tooth Enamel, A.A. Romanyukha, M.F. Desrosiers, D.F. Regulla, Appl. Radiat. Isot. 52 (2000) 1265-1273.

60. Advancements in Accuracy of the Alanine Dosimetry System. Part 2. The Influence of the Irradiation Temperature, V.Y. Nagy, J.M. Puhl, M.F. Desrosiers, Radiat. Phys. Chem. 57 (2000) 1-9.

59. Advancements in Accuracy of the Alanine Dosimetry System. Part 1. The Effects of Environmental Humidity, O.F. Sleptchonok, V.Y. Nagy, M.F. Desrosiers, Radiat. Phys. Chem. 57 (2000) 115-133.

58. Comment on Article by Haskell, Hayes, and Kenner, M.F. Desrosiers, V.Y. Nagy, A.A. Romanyukha, Health Physics 77 (1999) 470-471.

57. Radiation Processing Dosimetry Calibration Services: Manual of Calibration Procedures, J.C. Humphreys, J.M. Puhl, S.M. Seltzer, W.L. McLaughlin, M.F. Desrosiers, V.Y. Nagy, D.L. Bensen, M.L. Walker, NIST Special Publication 250-45, March 1998.

56. Radiation Processing Dosimetry Calibration Services and Measurement Assurance Program, J.C. Humphreys, J.M. Puhl, S.M. Seltzer, W.L. McLaughlin, M.F. Desrosiers, D.L. Bensen, M.L. Walker, NIST Special Publication 250-44, March 1998.

55. A Fluidized Bed Process for Electron Sterilization of Powders, S.V. Nablo, J.C. Wood, M.F. Desrosiers, V.Y. Nagy, Radiat. Phys. Chem. 52 (1998) 479-485.

54. Technical Aspects of the Electron Paramagnetic Resonance Method for Tooth Enamel Dosimetry, M.F. Desrosiers and A.A. Romanyukha, In, Biomarkers: Medical and Workplace Applications (M.L. Mendelsohn, L.C. Mohr, J.P. Peters, Eds.) Joseph Henry Press, Washington, DC (1998) pp. 53-64.

53. Reference Gamma-Ray Dosimetry and Calibration Traceability, W.L. McLaughlin, W.L., D.L. Bensen, M.F. Desrosiers, J.C. Humphreys, J.M. Puhl, and S.M. Seltzer, Proceedings of Mtg. IAEA Coordinated Research Programme on Characterization and Evaluation of High-Dose Dosimetry Techniques for Quality Assurance in Radiation Processing, October, 1997, Vienna Austria, International Atomic Energy Agency, IAEA TecDoc (1998).

52. Standard Practice for Use of the Alanine-EPR Dosimetry System, M.F. Desrosiers and A.H. Heiss, American Society for Testing and Materials, Designation E1607, 1994; revision February 1997.

51. Radiation Dosimetry of an Accidental Overexposure Using EPR Spectrometry and Imaging of Human Bone, D.A. Schauer, M.F. Desrosiers, P. Kuppusamy, J.L. Zweier, Appl. Radiat. Isot. 47 (1996) 1345-1350.

50. Choosing Reference Samples for EPR Concentration Measurements, Part 4. Systems of S=5/2, V. Yu. Nagy, D.P. Sokolov, M.F. Desrosiers, Anal. Chim. Acta 339 (1997) 53-62.

49. Choosing Reference Samples for EPR Concentration Measurements, Part 3. Systems of S=3/2, V. Yu. Nagy, P.N. Komozin, M.F. Desrosiers, Anal. Chim. Acta 339 (1997) 31-51.

48. Alanine EPR Dosimeter Response in Proton Therapy Beams, K. Gall, M.F. Desrosiers, D. Bensen, C. Serago, Appl. Radiat. Isot. 47 (1996) pp. 1197-1199.

47. The Current Status of the EPR Method for the Detection of Irradiated Foods, M.F. Desrosiers, Appl. Radiat. Isot. 47 (1996) pp. 1621-1628.

46. Critical Evaluation of the Sugar-EPR Dosimetry System, P. Fattibene, T. Duckworth, M.F. Desrosiers, Appl. Radiat. Isot. 47 (1996) pp. 1375-1379.

45. Inter-Laboratory Trials of the EPR Method for the Detection of Irradiated Spices, Nutshell, and Eggshell, M.F. Desrosiers, D.M. Yaczko, A. Basi, W.L. McLaughlin (1996) In, Detection Methods for Irradiated Food Current Status(C.H. McMurray, E.M. Stewart, R. Gray, J. Pearce, Eds.) Royal Soc. Chem. Special Publication No. 171, Cambridge, U.K., pp. 108-118.

44. A Complex Time Dependence of the EPR Signal of Irradiated L-α-Alanine, V. Yu. Nagy and M.F. Desrosiers, Appl. Radiat. Isot. 47 (1996) 789-793.

43. ESR Detection of Irradiated Meats, M. F. Desrosiers and W. L. McLaughlin, Proc. of IAEA Advisory Group, International Atomic Energy Agency, Vienna IAEA TecDoc (1996).

42. An Overview of an Accident at an Industrial Accelerator Facility, D.A. Schauer, B.M. Coursey, C.E. Dick, W.L. McLaughlin, J.M. Puhl, M.F. Desrosiers, A.D. Jacobson, Advances in the Treatment of Radiation Injuries, Vol. 94 (T.J. MacVittle, J.F. Weiss, D. Browne, Eds.) In, “Advances in the Biosciences”, Elsevier Science, Great Britain (1994) pp. 321-324.

41. Orientation Effects on ESR analysis of Alanine-Polymer Dosimeters, T. Kojima, S. Kashiwazaki, H. Tachibana, R. Tanaka, M.F. Desrosiers, W.L. McLaughlin, Appl. Radiat. Isot. 46 (1995) 1407-1411.

40. Investigation of Applicability of Alanine and Radiochromic Detectors to the Dosimetry of Proton Clinical Beams, D. Nichiporov, V. Kostjuchenko, J. Puhl, D. Bensen, M. Desrosiers, C. Dick, W. McLaughlin, T. Kojima, B. Coursey, S. Zink, Appl. Radiat. Isot. 46 (1995) 1355-1362.

39. Response to “Optimization of Experimental Parameters for the EPR Detection of the Cellulosic Radical in Irradiated Foodstuffs”, M.F. Desrosiers, D.L. Bensen D.M. Yaczko, Int. J. Food Sci. Tech. 30 (1995) 675-680.

38. Research and Development Activities in Electron Paramagnetic Resonance Dosimetry, M.F. Desrosiers, G. Burlinska, P. Kuppusamy, J. Zweier, D.M. Yaczko, F.P. Auteri, M.R. McClelland, C.E. Dick and W.L. McLaughlin, Radiat. Phys. Chem. 46 (1995) 1181-1184.

37. Dosimetry Systems for Radiation Processing, W.L. McLaughlin and M.F. Desrosiers, Radiat. Phys. Chem. 46 (1995) 1163-1174.

36. Inter-Laboratory Trials of the EPR Method for the Detection of Irradiated Meats Containing Bone, M.F. Desrosiers, F.G. Le, W.L. McLaughlin, Int. J. Food Sci.Tech. 29 (1994) 153-159.

35. EPR Dosimetry of Cortical Bone and Tooth Enamel Irradiated with X- and Gamma-Rays: An Energy-Dependence Study, D.A. Schauer, M.F. Desrosiers, F.G. Le, S.M. Seltzer, J.M. Links, Radiat. Res. 138 (1994) 1-8.

34. ESR-Based Analysis in Radiation Processing, W.L. McLaughlin, M.F. Desrosiers, M.C. Saylor, Sterilization of Medical Products, Vol. 6 (R. F. Morrisey, Ed.) Polysciences Publications Inc., Morin Heights, Canada (1993) pp. 213-239.

33. Estimation of the Absorbed Dose in Radiation-Processed Food. Part 4. EPR Measurements on Eggshell, M.F. Desrosiers, F.G. Le., P.M. Harewood, E.S. Josephson, M. Montesalvo, J. Agric. Food Chem. 41 (1993) 1471-1475.

32. A Radiation Accident at an Industrial Accelerator Facility, D.A. Schauer, B.M. Coursey, C.E. Dick, W.L. McLaughlin, J.M. Puhl, M.F. Desrosiers, A.D. Jacobson, Health Physics 65 (1993) 131-140.

31. Experimental Validation of Radiopharmaceutical Absorbed Dose to Mineralized Bone Tissue, M.F. Desrosiers, M.J. Avila, D.A. Schauer, B.M. Coursey, N.J. Parks, Appl. Radiat. Isot., 44 (1993) 459-464.

30. Estimation of the Absorbed Dose in Radiation-Processed Food. Part 3. The Effect of Time of Evaluation on the Accuracy of the Estimate, M.F. Desrosiers, F.G. Le, Appl. Radiat. Isot., 44 (1993) 439-442.

29. Electron Spin Resonance Investigations of Gamma-Irradiated Shrimp Shell, K.M. Morehouse and M.F. Desrosiers, Appl. Radiat. Isot., 44 (1993) 429-432.

28. A New EPR Dosimeter Based on Polyvinylalcohol, M.F. Desrosiers, J.M. Puhl, W.L. McLaughlin, Appl. Radiat. Isot., 44 (1993) 325-326.

27. EPR Bone Dosimetry: A New Approach to Spectral Deconvolution Problems, M.F. Desrosiers, Appl. Radiat. Isot., 44 (1993) 81-84.

26. A New Approach to Radiopharmaceutical Dose Assessment, M.F. Desrosiers and B.M. Coursey, Proceedings of the Fifth International Symposium on Radiopharmaceutical Dosimetry, CONF-910529 (E.E. Watson and A.T. Schlafke-Stelson, Eds.) Oak Ridge Associated Universities, Oak Ridge TN, (1992) p.p. 57-65.

25. Unusual Spin-Trap Chemistry for the reaction of Hydroxyl Radical with the Carcinogen N-Nitrosodimethylamine, D.A. Wink and M.F. Desrosiers, Radiat. Phys. Chem., 38 (1991) 467-472.

24. In Vivo Assessment of Radiation Exposure, M.F. Desrosiers, Health Physics,61 (1991) 859-861.

23. A Kinetic Investigation of Intermediates Formed During the Fenton Reagent-Mediated Degradation of N-Nitrosodimethylamine: Evidence for an Oxidative Pathway not Involving Hydroxyl Radical, D.A. Wink, R.W. Nims, M.F. Desrosiers, P.C. Ford, and L.K. Keefer, Chem. Res. Toxic., 4 (1991) 510-512.

22. Electron Spin Resonance Methods for Monitoring Radiation-Processed Meats Containing Bone, M.F. Desrosiers, J. Food Science, 56 (1991) 1104-1105.

21. Estimation of the Absorbed Dose in Radiation-Processed Food. Part 2. Test of the EPR Response Function by an Exponential Fitting Analysis, M.F. Desrosiers, Appl. Radiat. Isot., 42 (1991) 617-619.

20. Estimation of the Absorbed Dose in Radiation-Processed Food. Part 1.Test of the EPR Response Function by a Linear Regression Analysis, M.F. Desrosiers, G.L. Wilson, C.R. Hunter, and D.R. Hutton, Appl. Radiat. Isot.,42 (1991) 613-616.

19. Radiopharmaceutical Dose Assessment, M.F. Desrosiers, B.M. Coursey, M.J. Avila, and N.J. Parks, Nature, 349 (1991) 287-288.

18. Co-Trial on Identification and Estimates of Gamma-Ray and Electron Absorbed Doses Given to Meat and Bones, M.F. Desrosiers, W.L. McLaughlin, L.A. Sheahen, N.J.F. Dodd, J.S. Lea, J.C. Evans, C.C. Rowlands, J.J. Raffi, J.-P.L. Agnel, Int. J. Food Sci. Tech., 25 (1990) 682-691.

17. Assessing Radiation Dose to Food, M.F. Desrosiers, Nature, 345 (1990) 485.

16. Onion Skin as a Radiation Monitor, M.F. Desrosiers and W.L. McLaughlin, Radiat. Phys. Chem., 35 (1990) 321-323.

15. ESR Detection of Irradiated Meats, M. F. Desrosiers and W. L. McLaughlin, Proc. of IAEA Coordinated Research Meeting, Warsaw, Poland, (1990).

14. Some Recent Developments in Ionizing Radiation Chemical Dosimetry, M. L. Walker, D. S. Bergtold, B. M. Coursey, M. F. Desrosiers, L.R. Karam, and W. L. McLaughlin, Proc. Annual Meeting of National Organization for the Professional Advancement of Black Chemists and Chemical Engineers, Chicago, IL (1989).

13. Examination of Gamma-Irradiated Fruits and Vegetables by Electron Spin Resonance Spectroscopy, M.F. Desrosiers and W.L. McLaughlin, Radiat. Phys. Chem., 34 (1989) 895-898.

12. Mechanically-Induced Generation of Radicals in Tooth Enamel, M. F. Desrosiers, M. G. Simic, F. C. Eichmiller, A. D. Johnston, R. L. Bowen, Appl. Radiat. Isot., 40 (1989) 1195-1197.

11. The Effect of Oxygen, Antioxidants, and Superoxide Radical on Tyrosine Phenoxyl Radical Dimerization, E.P.L. Hunter, M.F. Desrosiers, M.G. Simic, J. Free Rad. Biol. Med. 6 (1989) 581-585.

10. Gamma-Irradiated Seafoods: Identification and Dosimetry by Electron Paramagnetic Resonance Spectroscopy, M. F. Desrosiers, J. Agric. Food Chem. 37 (1989) 96-100.

9. Post-Irradiation Dosimetry of Meat by Electron Spin Resonance Spectroscopy of Bones, M.F. Desrosiers, M.G. Simic, J. Agric. Food Chem. 36 (1988) 601-603.

8. Peptide Irradiation Products and Crosslinking Mechanisms, L. R. Karam, M. F. Desrosiers, M. G. Simic, Proceedings of the Eighth International Congress on Radiation Research, Vol. 2 (E. M. Fielden, J. F. Fowler, J. H. Hendry, D. Scott, Eds.) Taylor & Francis, London (1987) p.p. 146.

7. Olefin Radical Cations in Pulse Radiolysis of Hydrocarbons, Time-Resolved Fluorescence Detected Magnetic Resonance, D.W. Werst, M.F. Desrosiers, A.D. Trifunac, Chem. Phys. Lett., 133 (1987) 201-206.

6. Structure and Dynamics of Olefin Radical Cation Aggregates, Time-Resolved Fluorescence Detected Magnetic Resonance, M.F. Desrosiers, A.D. Trifunac, J. Phys. Chem. 90 (1986) 1560-1564.

5. Detection of Aromatic Radical Cation Aggregates in Pulse Radiolysis in Alkane Solutions, M.F. Desrosiers, A.D. Trifunac, Chem. Phys. Lett., 121 (1985) 382-385.

4. Observation of Transient Cyclohexene and 1,4-Cyclohexadiene Radical Cations. Time-Resolved Fluorescence Detected Magnetic Resonance, M.F. Desrosiers, A.D. Trifunac, Chem. Phys. Lett. 118 (1985) 441-443.

3. Photoreactions of the Triruthenium Cluster Ru₃(CO)₁₂ and Its Substituted Analogues, M.F. Desrosiers, D.A. Wink, P.C. Ford, R.T. Trautman, D.A. Wink, P.C. Ford, Inorganic Chemistry 24 (1985) 1-2.

2. Flash Photolysis of Ru₃(CO)₁₂: Evidence for Intermediates in the Competing Fragmentation and Ligand-Substitution Photoreactions, M.F. Desrosiers, J. Am. Chem. Soc. 108 (1986) 1917-1927.

1. Photochemical Fragmentation of the Cluster Ru₃(CO)₁₂: Evidence Against Homolytic Bond Cleavage, M.F. Desrosiers, P.C. Ford, Organometallics 1 (1982) 1715-1716.